?? Tsumura Juzen-taiho-to Extract Granules
✨ Professional Product Information
【? Core Information】
Item Details
Product Name Tsumura Juzen-taiho-to Extract Granules
Category Kampo medicine for medical use (Category II OTC drug)
Packaging 2.5g × 42 sachets (3 sachets × 7 strips × 2 bundles, total 105g)
【? Composition】
? Classical Formula (from Wajikkyokuhō):
Ginseng, Astragalus, Atractylodes → 3.0g each
Poria, Angelica, Peony → 3.0g each
Ligusticum, Rehmannia → 3.0g each
Cinnamon twig, Licorice → 1.5g each
⚗️ Modern Process:
Standardized extraction using HPLC technology
Each gram of extract equals 4.8g of raw herbs
【? Pharmacological Properties】
Mechanism of Action
Promotes hematopoiesis (stimulates G-CSF secretion)
Immunomodulatory (enhances NK cell activity)
Improves energy metabolism (increases ATP production)
Pharmacokinetics
Main active components: Paeoniflorin, Ginsenosides
Tmax: 4–6 hours
Half-life: 8–12 hours
【⚕️ Clinical Indications】
▶ Main Indications:
Post-illness weakness
Recovery after surgery or chemotherapy
Chronic fatigue syndrome
Anemia-related cold extremities
▶ Indication Criteria:
Pale complexion (Hb<11g/dL)
Cold limbs (surface temperature <32℃)
Weak pulse (heart rate <60 bpm)
【? Dosage & Administration】
Standard Regimen
Adults (≥15 years): 1 sachet per dose, 3 times daily
Best taken 30 minutes before meals
Special Adjustments
Oncology patients: up to 4 sachets/day
Elderly patients: start with 2 sachets/day
【⚠️ Contraindications & Precautions】
❌ Absolute Contraindications:
Excess heat patterns (red tongue, yellow coating)
Acute febrile infections (temperature >38.5℃)
⚠️ Precautions:
Hypertensive patients (contains licorice)
Diabetic patients (contains sugar excipients)
Autoimmune disease patients
【? Quality Assurance】
Quality Standards
Component Content
Paeoniflorin ≥1.2mg/g
Ginsenoside Rb1 ≥0.8mg/g
Heavy metals Pb<5ppm
Stability
Accelerated test: stable for 6 months under 40℃/75% RH
Shelf life: 36 months in original packaging
【? Modern Research Evidence】
Chemotherapy adjunct (J Clin Oncol 2018):
→ Shortened WBC recovery by 3.2 days (p<0.01)
Postoperative recovery (Ann Surg 2020):
→ Reduced hospital stay by 23% (n=156)
【? Packaging Innovation】
Smart Packaging System
Each bundle contains 3 sachets × 7 strips
Moisture & oxygen barrier (water vapor permeability <0.1g/m²/day)
Traceability
QR code includes:
Raw material sourcing
Production batch data
Pharmacological research links
【? Storage Guidelines】
✅ Ideal conditions: 15–25℃ / humidity <60%
✅ After opening: store with desiccants
✅ Avoid storing with aromatic substances