What is Hyperlipidemia?

Hyperlipidemia refers to abnormally elevated levels of lipids such as cholesterol and triglycerides in the blood. It is a major risk factor for atherosclerosis, coronary artery disease, and stroke. Often asymptomatic for years, hyperlipidemia silently damages blood vessels and has earned the name “silent killer.”

Common Types of Hyperlipidemia

Hypercholesterolemia: Elevated levels of LDL cholesterol (“bad” cholesterol).

Hypertriglyceridemia: High triglyceride (TG) levels, which in severe cases may trigger pancreatitis.

Mixed Hyperlipidemia: Multiple lipid abnormalities present simultaneously.

Hyperlipidemia is commonly found in people who are sedentary, consume fatty or sugary diets, are overweight, or have a family history of lipid disorders. Regular lipid panel screening is recommended for adults over 30.

Intervention: Combine Lifestyle Changes with Medication

1. Lifestyle Modifications

Dietary Adjustments: Reduce intake of animal fats, sugary foods, and fried items.

Physical Activity: At least 150 minutes of moderate-intensity aerobic exercise per week.

Weight Management: Losing weight can significantly improve lipid profiles.

Quit Smoking and Limit Alcohol: This helps raise HDL (“good” cholesterol) levels.

For people with mild to moderate hyperlipidemia, lifestyle modification is the first-line treatment. If lipid levels remain abnormal after 3 to 6 months or are severely elevated, medication should be considered.

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? Medication Therapy: Understanding Fenofibrate (フェノフィブラート)

In Japan, Fenofibrate (Lipidil) is a commonly prescribed lipid-lowering medication, especially effective for patients with elevated triglycerides or mixed hyperlipidemia.

? Basic Information

Active Ingredient: Each tablet contains 80 mg of fenofibrate.

Main Effects:

Reduces triglycerides (TG)

Lowers LDL cholesterol ("bad" cholesterol)

Increases HDL cholesterol ("good" cholesterol)

Indications:

Primary hyperlipidemia

Familial hypercholesterolemia

Dosage: Typically taken once or twice daily after meals.

⚠️ Possible Side Effects

Common side effects may include:

Gastrointestinal symptoms (e.g., bloating, nausea)

Skin issues such as itching or photosensitivity

In rare cases, gallstones or liver dysfunction

Seek immediate medical attention if you experience right upper abdominal pain, jaundice, or dark-colored urine.

✅ Usage Recommendations

Always use under medical supervision

Regularly monitor liver/kidney function and blood lipid levels

Maintain a healthy diet—do not rely on the medication to "offset" poor eating habits

If combined with statins, closely follow your doctor's instructions to avoid the risk of rhabdomyolysis (a serious muscle condition)

? Practical Tips

Condition Recommendation

Elevated triglycerides only Fenofibrate shows excellent results, better than statins

High LDL only Prioritize statins; fenofibrate may be added if needed

Mixed hyperlipidemia Requires personalized treatment—fenofibrate is important

Kidney or liver disease Use with caution; frequent function monitoring is essential

? Summary

Hyperlipidemia often has no symptoms, but the risks are real and serious.

Lifestyle intervention is the foundation, but medication provides necessary support.

Fenofibrate (フェノフィブラート) from Japan is proven effective across various types of dyslipidemia.

Always follow your doctor’s guidance, go for regular checkups, and never adjust your dosage without medical advice.