Kremezin Fast-Dissolving Tablets 500mg – 336 Tablets

Chronic Renal Failure | Kidney Failure | Renal Insufficiency | Uremia | Delays Dialysis Initiation

? Product Overview

Kremezin is an oral adsorbent developed by Mitsubishi Tanabe Pharma Corporation in Japan. Its main active ingredient is Spherical Carbon Adsorbent (SCA).

It is primarily prescribed to patients with progressive chronic kidney disease (CKD) to help reduce the accumulation of uremic toxins and delay the initiation of dialysis.

⚙️ Mechanism of Action

As CKD progresses, the kidneys lose their ability to eliminate waste products efficiently, leading to the buildup of uremic toxins (e.g., indole derivatives) in the body.

Kremezin works through the following mechanisms:

Adsorbs toxin precursors in the gastrointestinal tract;

Prevents the absorption of harmful substances into the bloodstream;

Eliminates them via feces;

Reduces systemic toxin levels and relieves uremic symptoms;

Helps delay the need for dialysis.

✅ Indications & Therapeutic Benefits

[Approved Indication]

Improves uremic symptoms associated with progressive chronic renal failure;

Delays the initiation of dialysis in patients with progressive CKD.

[Eligibility Criteria]

Kremezin should only be used under the following clinical conditions:

The patient is diagnosed with progressive CKD and is undergoing conservative treatment;

The patient's serum creatinine (S-Cr) levels show a moderate or faster rate of increase:

? S-Cr Criteria: Rate of increase (1/S-Cr per month) ≥ 0.01 dL/mg

One Month Ago (mg/dL) Current Value (mg/dL) Meets Criteria?

2.9 3.0 ✔️

4.8 5.0 ✔️

6.5 7.0 ✔️

? Dosage & Administration

Recommended dosage: 1 sachet (2g) per dose, 3 times daily for adults;

Timing: Ideally taken 2 hours after meals or between meals;

Maintain a 30-minute to 1-hour gap when taking other medications.

? Tips for Use:

If a dose is missed, take it as soon as possible unless it's close to the next dose;

Do not double the dose to make up for a missed one;

In case of accidental overdose, seek medical attention immediately;

Do not discontinue the medication without medical advice.

⚠️ Common Side Effects

Kremezin is generally well-tolerated, but possible side effects include:

Gastrointestinal symptoms: constipation, nausea, vomiting, abdominal bloating, loss of appetite, diarrhea;

Skin reactions: rash, itching.

Seek medical attention if any adverse effects become severe.

? Precautions Before Use

Inform your doctor if:

You have a history of allergic reactions to medications or foods;

You have gastrointestinal obstruction or strictures;

You are pregnant or breastfeeding;

You are taking other medications (including OTC supplements or herbal remedies), as drug interactions may occur.

⚠️ Always follow your physician’s instructions closely.

? Storage & Disposal

Store at room temperature, away from direct sunlight, heat, and moisture;

Keep out of reach of infants and children;

Properly discard any unused medication—do not share with others.

? Product Information Summary

Item Description

Product Name Kremezin (Spherical Carbon Adsorbent)

Dosage Form Granules

Active Ingredient Spherical Carbon Adsorbent (SCA)

Indications Improves uremic symptoms and delays dialysis in CKD

Dosage 1 sachet, 3 times daily (oral use)

Manufacturer Mitsubishi Tanabe Pharma Corporation (Japan)

✅ Conclusion

For patients with progressive CKD undergoing conservative treatment, Kremezin offers a valuable non-dialysis option by reducing the burden of uremic toxins and delaying the need for renal replacement therapy. It is a well-established therapy in Japan and should be used under strict medical supervision for optimal results.