Sawai Theophylline Sustained-Release Tablets 100mg: A Trusted Bronchodilator for Chronic Respiratory Diseases
In the treatment of respiratory diseases, bronchodilators remain a fundamental and essential therapeutic option. They not only effectively relieve bronchoconstriction-induced breathing difficulties but also significantly improve patients’ quality of life. Among various bronchodilators, the Theophylline Sustained-Release Tablets produced by Sawai Pharmaceutical Co., Ltd. (Japan) have earned widespread trust among clinicians and patients alike, thanks to their time-tested active ingredient, sustained-release formulation, and reliable efficacy.
Key Ingredient and Pharmacological Action
The main active ingredient of Sawai Theophylline SR Tablets is theophylline, with each tablet containing 100mg. As a xanthine derivative, theophylline exerts multiple pharmacological effects, including:
Bronchodilation
Stimulation of the respiratory center
Enhancement of diaphragmatic contractility
This medication utilizes a sustained-release mechanism to continuously relax airway smooth muscles and reduce airway resistance. It effectively manages both acute and chronic symptoms of respiratory diseases such as:
Bronchial asthma
Asthmatic bronchitis
Chronic bronchitis
Pulmonary emphysema
Symptoms controlled include coughing, sputum production, wheezing, and shortness of breath.
The sustained-release design is particularly suitable for patients with chronic respiratory conditions requiring stable plasma drug concentrations over time.
Indications and Dosage
Target patient groups include both adults and children, particularly those with:
Frequent nocturnal or early morning asthma attacks
Persistent dyspnea due to chronic bronchitis or emphysema
Poor response to short-acting bronchodilators requiring long-term management
Recommended dosage:
Adults: 200mg (2 tablets) twice daily (morning and bedtime);
For nocturnal asthma, 400mg (4 tablets) may be taken once at bedtime.
Children: 100–200mg (1–2 tablets) twice daily;
Dosage should be individualized based on weight, age, and disease condition under medical supervision.
⚠️ Important: Due to theophylline's narrow therapeutic window, regular monitoring of serum theophylline levels is strongly recommended. Dose adjustments should be made under the guidance of a healthcare professional.
Key Advantages
1. Stable, Long-Acting Release Mechanism
Compared with immediate-release formulations, the sustained-release version ensures consistent plasma concentration over time, prolonging therapeutic effects and reducing dosing frequency—thus enhancing patient compliance.
2. Broad Spectrum of Indications
Effective for multiple respiratory conditions, including COPD and asthma-related disorders. Theophylline is also a valuable adjunct or alternative when inhaled corticosteroids or β2-agonists provide insufficient relief.
3. Reliable Long-Term Control
Regular use helps reduce exacerbation frequency, manage chronic inflammation, and improve patients’ daily function and quality of life. Especially for elderly patients with chronic pulmonary diseases, Sawai’s theophylline offers a cost-effective, safe, and stable long-term therapy.
Precautions and Potential Side Effects
While generally effective, improper use or individual metabolic variations may lead to side effects:
Common adverse reactions include:
CNS effects: headache, insomnia, anxiety, tremor
Cardiovascular: palpitations, arrhythmia
Gastrointestinal: nausea, vomiting, loss of appetite, abdominal discomfort
In children: irritability, restlessness, poor appetite
Safe use recommendations:
Regular monitoring of serum theophylline levels (recommended range: 5–15 mcg/mL)
Avoid co-administration with drugs that affect theophylline metabolism (e.g., erythromycin, quinolone antibiotics)
Use with caution in patients with a history of arrhythmia, epilepsy, or hepatic/renal impairment
Special care should be taken when prescribing to children or the elderly, with close observation for adverse effects.
Conclusion
As a classic bronchodilator, Sawai Theophylline SR Tablets have become a reliable treatment choice for patients worldwide, thanks to their advanced formulation, broad indications, lasting efficacy, and established safety profile.
For those suffering from asthma, COPD, or other chronic respiratory conditions, this medication offers not just symptom relief, but a path toward regaining respiratory freedom and improving daily life. When used under proper medical guidance and in combination with a healthy lifestyle, Sawai Theophylline SR Tablets can serve as a steadfast partner in long-term respiratory care.