Many women experience intense and sometimes unbearable pain during their menstrual periods, including
lower abdominal cramping, lower back and sacral pain, and symptoms severe enough to interfere with daily work and life.
For a significant number of women, this pain is not just “normal period pain”, but is related to endometriosis.
Today, we take a closer look at a prescription medication widely used in clinical practice in Japan — Relumina® tablets.
What Is Endometriosis?
Under normal circumstances, the endometrial tissue exists only inside the uterine cavity.
In endometriosis, however, endometrial tissue grows outside the uterus, such as in:
The ovaries
The pelvic peritoneum
Around the fallopian tubes
These ectopic lesions are still influenced by female hormones and change with the menstrual cycle, which can lead to:
Severe menstrual pain
Chronic pelvic pain
Pain during sexual intercourse
An increased risk of infertility
What Is Relumina® Tablets?
The generic name of Relumina® tablets is relugolix.
It is a GnRH receptor antagonist and an oral prescription medication.
It is not a painkiller, but a therapeutic drug that regulates hormones at their source.
How Does It Work?
Simply put, the mechanism of action of Relumina® tablets can be understood in three steps:
1、 Inhibits GnRH receptors in the pituitary gland
2、 Reduces the secretion of gonadotropins
3、 Lowers estrogen levels
Estrogen is a key factor in the growth and maintenance of endometriosis lesions.
When estrogen levels are suppressed:
The activity of ectopic endometrial tissue decreases
Inflammatory responses are reduced
Pain symptoms are gradually relieved
---- This is cause-targeted treatment, rather than simply masking symptoms.
Main Indications and Key Characteristics
In clinical practice in Japan, Relumina® tablets are mainly used for:
Improvement of pain associated with endometriosis
Relief of menstrual pain and chronic pelvic pain
Suppression of lesion progression
Key characteristics include:
--- Oral administration with good adherence
--- Relatively clear onset of action
--- A non-surgical treatment option
--- Suitable for patients requiring long-term management
How Is It Different From Traditional Treatment Options?
What Should Be Considered During Use?
It is a prescription medication and must be used under a physician’s guidance.
Hormone-related responses should be monitored during treatment.
It is not suitable for unsupervised long-term use.
? The specific treatment plan and duration depend closely on individual conditions and should be determined by a medical professional.
Relumina® tablets improve pain caused by endometriosis by suppressing estrogen secretion at its source, providing a systematic management approach.